James Bruckner, Professor
Participated in a review and meeting of the EPA Science Advisory Board that reviewed and evaluated a report entitled “Assessment of the Potential Impacts of Hydraulic Fracturing on National Drinking Water Resources.”
This is an assessment of whether high pressure injection of fluid and chemicals in oil and gas wells is significantly affecting the quality and quantity of the nation’s ground and surface water.
Presented the following poster at the annual meeting of the Society for Neuroscience on October 18th: The effect of the mitochondria-targeted antioxidant MitoQ on memory retention and neuropathology in aged 3xTg-AD mice
Zhen Han; Yepeng Luan; Yujun George Zheng (2015) “Integration of Bioorthogonal Probes and Q-FRET for the Detection of Histone Acetyltransferase Activity.” ChemBioChem. Ahead of Print.
Linna Yan, Kexiu Song, Mingming Gao, Shen Qu and Dexi Liu (2015). Modulation of Cell-mediated Immunity to Suppress High Fat Diet-induced Obesity and Insulin Resistance, Pharmaceutical Research, DOI 10.1007/s11095-015-1797-9.
Mohammad Alsaggar, Qian Yao, Houjian Cai and Dexi Liu (2015) Differential Growth and Responsiveness to Cancer Therapy of Tumor Cells in Different Environments. Clinical and Experimental Metastasis. DOI 10.1007/s10585-015-9761-y
Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Kenya Kamimura, Dexi Liu and Shuji Terai (2015). Site-specific Impact of a Regional Hydrodynamic Injection: Computed Tomography Study during Hydrodynamic Injection Targeting the Swine Liver, Pharmaceutics. 7:334-343.
Mohammad Alsaggar and Dexi Liu (2015) Liver-Targeted Gene and Cell Therapy – An Overview. In “Gene Therapy and Cell Therapy through the Liver” Edited by Shuji Terai and Takeshi Suda, Springer Japan KK, Tokyo, Japan, pp 1-11.
Kenya Kamimura, Hiroyuki Abe, Yuji Kobayashi, Takeshi Suda, Yutaka Aoyagi and Dexi Liu (2015). Image-guided Hydrodynamic Gene Delivery to Liver: Toward Clinical Applications. In “Gene Therapy and Cell Therapy through the Liver” Edited by Shuji Terai and Takeshi Suda, Springer Japan KK, Tokyo, Japan, pp 85-92.
X. Yang, I. Poddar, C.M. Hernandez, A.V. Terry, M.G. Bartlett, “Simultaneous quantitation of quetiapine and its active metabolite norquetiapine in rat plasma and brain tissue by high performance liquid chromatography / electrospray ionization tandem mass spectrometry (LC-MS/MS).” Journal of Chromatography B, 1002, 71-77 (2015).
Dr. Bartlett also co-presented, The application of de novo peptide sequencing for characterization of cetrorelix acetate and its related impurities, with S. Hooshfar and F. Kobarfard at the 29th National Meeting of the American Association for Pharmaceutical Scientists in Orlando, FL on November 2015.
Mandi Murph, Associate Professor
Served as a grant reviewer for the Ovarian Cancer Research Program for the Department of Defense Congressionally Directed Medical Research Programs, October 1-2, 2015, and also served as the session chair for several discussions when the established chair had conflicts of interest with the proposals.
Dr. Murph also gave an invited talk about her research on the RGS10 protein at the 25th Annual Keck Center Research Conference: A Quarter Century of Team Science, in Houston, Texas, October 16, 2015.
Brian Cummings, Associate Professor
Served as Chair for the Department of Defense Prostate Cancer Research Program Grant Review Panel on Clinical Experimental Therapeutics held on October 14th and 15th
Dr. Cummings also presented a Plenary Lecture titled “Blood Lipid Indicators of Drug Abuse and Addiction” at the Howard C. Ansel Symposium held October 23rd, 2015 at the College of Pharmacy.
Dr. Beedle served as a grant reviewer for the Muscular Dystrophy Association Research Grant and Development Grant programs on the Scientific Advisory Committee, October 9, 2015, Washington DC.
Dr. Pegan received an annual continuation of funding in the amount of $308,078 from the National Institutes of Health for the project titled, ORIGIN OF THE INNATE IMMUNITY SUPPRESSION CA– USED BY NAIROVIRUS’ PROTEASE ACTIVITY.
He also has been busy publishing, Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX. Daczkowski CM, Pegan SD, Harvey SP. Biochemistry. 2015 Oct 20;54(41):6423-33. doi:10.1021/acs.biochem.5b00624. Epub 2015 Oct 6
And…presenting, “A journey into the world of nairovirus ovarian tumor domain proteases and implications for therapeutic discovery,” Mercer University College of Pharmacy, October 19th, 2015.
Resistance to chemotherapy is a major problem for those suffering from ovarian cancer. University of Georgia researchers are giving patients new hope with recent findings that help pinpoint the mechanisms causing chemoresistance.
Over the last five years, UGA College of Pharmacy associate professors Mandi Murph and Shelley Hooks have discovered that a type of protein known as RGS10 impacts the effectiveness of ovarian cancer chemotherapy. Murph also discovered that mTOR signaling, a protein encoded by the mTOR gene, drives the effects of RGS10. Continued…