UGA researchers discover mechanism that could lead to better ovarian cancer treatment

shelley b. hooks

Dr. Shelley Hooks


Dr. Mandi Murph

Resistance to chemotherapy is a major problem for those suffering from ovarian cancer. University of Georgia researchers are giving patients new hope with recent findings that help pinpoint the mechanisms causing chemoresistance.

Over the last five years, UGA College of Pharmacy associate professors Mandi Murph and Shelley Hooks have discovered that a type of protein known as RGS10 impacts the effectiveness of ovarian cancer chemotherapy. Murph also discovered that mTOR signaling, a protein encoded by the mTOR gene, drives the effects of RGS10.  Continued…