Election to NAI Fellow status is a professional distinction accorded to academic inventors who have demonstrated a prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development and the welfare of society. Five UGA faculty members have been named NAI Fellows since the honor was established in 2013.
Chung K. “David” Chu is a Distinguished Research Professor Emeritus in the department of pharmaceutical and biomedical sciences. His research focuses on nucleoside and carbohydrate chemistry, antiviral chemotherapy, cancer chemotherapy, structure-based drug design and molecular modeling and antiviral drug discovery for bioterrorism. His antiviral drug clevudine, marketed under the trade names Levovir and Revovir, is used in the treatment of chronic hepatitis B infections in South Korea and the Philippines.
“Dr. Chu is one of the most prolific and productive inventors at the University of Georgia,” Lee said. “His work has led to dozens of inventions and patents, and his development of clevudine has improved the lives of countless individuals suffering from hepatitis B.”
He is the recipient of numerous prestigious awards, including the NIH Merit Award, the UGA Inventor of the Year Award and the John A. Montgomery Award, which is given biannually to an outstanding scientist in recognition of a contribution that results in significant advances in chemotherapy.
Chu holds 63 U.S. patents and more than 130 international patents that have been licensed to 10 companies. He is a co-founder of both Pharmasset, which was acquired by Gilead for $11 billion in 2011, and, more recently, he co-founded Atea Pharmaceuticals to explore novel antiviral therapeutics.
Chu has published over 315 peer-reviewed journal articles and served on the editorial advisory board for the journal Nucleoside, Nucleotide and Nucleic Acids. He is a fellow of the American Association for the Advancement of Science, a national board member of Florida A&M University’s College of Pharmacy, a Dean’s Advisory Council member of Idaho State University’s College of Pharmacy and a National Institutes of Health advisory committee member.
Although officially retired, Chu maintains an active research program on drug synthesis and is currently developing treatments for hepatitis B and C infections.
Conference Abstract and Poster Presentation:
Daczkowski C, Deaton M, Jenkins B, Mank N, Bergeron E, Pegan SD., “Development of vaccine candidates through ablation of viral deubiquitinase and deISGylase activities,” 2015 UGA Conference on Drug Discovery, November 17, 2015
Nguyen HT, Jia W, Beedle AM, Kennedy EJ, Murph MM. Lysophosphatidic Acid Mediates Activating Transcription Factor 3 Expression Which Is a Target for Post-Transcriptional Silencing by miR-30c-2-3p. PLoS One. 2015 Sep 29;10(9):e0139489. doi: 10.1371/journal.pone.0139489. eCollection 2015. PMID: 26418018
Posters presented at the UGA Center for Drug Discovery Conference in Athens GA:
SJ Foltz, A Patel, KB Peissig and AM Beedle. Therapeutic targeting of Akt/mTOR signaling in Fktn-deficient muscle.
YM Wang, SK Hekmatyar, SJ Foltz and AM Beedle. Evaluation of MRI for phenotypic assessment in a mouse model of muscular dystrophy.
Beedle lab graduate student Steven Foltz won a Student Poster Presentation Prize at the UGA Center for Drug Discovery Conference November 19th in Athens
Dr. James Bruckner was invited to serve a second 3-year term as a member of the U.S.EPA Science Advisory Board Chemical Assessment Advisory Committee. This committee evaluates major national contamination problems and makes recommendations to the EPA Administrator for alternative courses of action.
Dr. Beedle lab graduate student, Steven Foltz and Dr. Liu lab graduate student, Hao Sun both won a Student Poster Presentation Prize at the UGA Center for Drug Discovery Conference on November 19 in Athens.
Dr. Liu presented a seminar entitled, “Tuning–up Gene Expression to Prevent and Treat Obesity and Obesity-associated Insulin Resistance,” at the Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy on November 3, 2015.
As well, he published two book chapters:
Yahya Alhamhoom, Mohammad Alsaggar & Dexi Liu (2015) Future Perspective: Toward Targeting at the Cellular Level. Advances and Challenges in the Delivery of Nucleic Acid Therapeutics (Volume 2). Pages 2-17, Doi: 10.4155/fseb2013.14.10
Kenya Kamimura, Takeshi Suda & Dexi Liu (2015) Hydrodynamic Gene Delivery. Advances and Challenges in the Delivery of Nucleic Acid Therapeutics (Volume 2) Pages 42-57, Doi: 10.4155/fseb2013.13.103
Dr. Liu also co-organized the session titled “NIH Programs & Funding Opportunity for Pharmaceutical Scientists” at the 2015 AAPS Annual Meeting and Exposition on October 25-29, 2015 at the Orange County Convention Center in Orlando, Florida.