Dr. Eileen Kennedy recently published a paper in Nature Methods: “Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution. Nature Methods, (2017) doi:10.1038/nmeth.4221. Briefly, the article states that compartmentalized biochemical activities are essential to all cellular processes, but there is no generalizable method to visualize dynamic protein activities in living cells at a resolution commensurate with cellular compartmentalization. In the article, the authors introduce a new class of fluorescent biosensors that detect biochemical activities in living cells at a resolution up to threefold better than the diffraction limit. The findings suggest that biochemical activities of the cell are spatially organized into an activity architecture whose structural and functional characteristics can be revealed by these new biosensors.