James V. Bruckner, Ph.D. Professor Pharmaceutical and Biomedical Sciences Office: Room 356, R.C. Wilson Pharmacy Phone: (706) 542-5405 E-mail: bruckner@rx.uga.edu

Biosketch

B.S. Pharmacy	University of Texas	Austin, Texas	1968
M.S. Toxicology	University of Texas	Austin, Texas	1971
Ph.D. Toxicology	University of Michigan	Ann Arbor, Michigan	1974
Assistant Professor	University of Kansas	Lawrence, Kansas	1974-75
Assistant Professor	University of Texas Medical School	Houston, Texas	1975-83
Associate Professor	University of Georgia	Athens, Georgia	1983-92
Professor	University of Georgia	Athens, Georgia	1992-Present

Honors and Awards
Member of the Committee on Use of Human Subjects in Toxicology Research, Policy and Global Affairs Division, National Academy of Sciences
Member of the Committee on Toxicology, Board on Environmental Studies & Toxicology, National Academy of Sciences
Award for outstanding contributions in development of the Acute Exposure Guidelines for Hazardous Substances Program, by former Vice President Al Gore
Member of the Food Quality Protection Act Science Review Board, Office of Prevention, Pesticides and Toxic Substances, U.S. EPA

Research Interests
The major focus of ongoing research is on basic toxicology and pharmacokinetic questions that impact assessments of risks of chemicals to human health. Emphasis in the lab is currently on volatile organic chemicals (VOCs) and pesticides. High, lifetime doses of VOCs cause cancer in mice and rats, but it is unclear whether low, environmental exposures pose a cancer risk to humans. Animal studies are being conducted to determine the effectiveness of detoxification presystemic elimination, and other protective mechanisms against trace-level exposures. Studies are also conducted to learn whether drug-chemical interactions are of consequence under these conditions. Work is underway to develop physiologically-based pharmacokinetic models for predicting risks of pyrethroid pesticides to children's health. Grants from the EPA, DOE and CDC support these activities.

Representative Publications
K.-B. Kim, S. S. Anand, S. Muralidhara, H. J. Kim, and J. V. Bruckner, Formulation-Dependent Toxicokinetics Explains Differences in the GI Absorption, Bioavailability and Acute Neurotoxicity of Deltamethrin in Rats, Toxicolog, 2007, 234: 194-202.

S.S. Anand, K.-B. Kim, S. Padilla, S. Muralidhara, H.J. Kim, J.W. Fisher, and J.V. Bruckner, Ontogeny of Hepatic and Plasma Metabolism of Deltamethrin in vitro: Role in Age-Dependent Acute Neurotoxicity, Drug Metab. Dispos. 2006, 34: 389-397.

A. Mirfazaelin, K.-B. Kim., S.S Anand, H. J. Kim, J. V. Bruckner, and J. W. Fisher, Development of a Physiologically Based Pharmacokinetic Model for Deltamethrin in the Adult Sprague-Dawley Rat, Toxicology Science, 2006, 93: 432-442.

G. Daston, E. Faustman, G. Ginsberg, P. Fenner-Crisp, S. Olin, B. Sonawane, J.V. Bruckner, and W. Breslin, A Framework for Assessing Risks to Children from Exposure to Environmental Agents, Environmental Health Perspective, 2004, 112: 238-256.

M.H. Lumpkin, J.V. Bruckner, J. L. Campbell, C.E. Dallas, C.A.White, and J.W. Fisher, Plasma Binding of Trichloroacetic Acid in Mice, Rats and Humans Under Cancer Bioassay and Environmental Exposure Conditions, Drug Metab. Dispos., 2003, 31: 1203-1207.