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Catherine A. White, Ph.D.
Associate Professor
Pharmaceutical and Biomedical Sciences
Office: Room 215, R.C. Wilson Pharmacy
Phone: (706) 542-5762
E-mail: cwhite@rx.uga.edu
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Biosketch
| B.S., Pharmacy | St. Louis College of Pharmacy | St. Louis, MO | 1980 | | Ph.D., Pharmaceutical Sciences | Univerisity of Washington | Seattle, WA | 1986 | | Postdoctoral Fellowship | University of Kansas Medical Center | Kansas City, KS | 1987 | | Assistant Professor | University of Houston | Houston, TX | 1987-1993 | | Assistant Professor | University of Georgia | Athens, GA | 1993-1997 | | Associate Professor | University of Georgia | Athens, GA | 1997-date |
Honors and Awards
Member, Board of Directors, International Society of Medical Chronobiology
Director, Educational and Training Programs for CLEARMADD Research Interests
Gender may influence the pharmacokinetics and efficacy/toxicity of drugs and herbal products. Women experience a higher incidence of adverse drug reactions and the cause of this is unknown. The pharmacokinetics of the drugs may be influenced by gender or the pharmacodynamics may be altered. Our research group is examining the influence of gender on the clearance mechanisms of various drugs and on the pharmacokinetics and toxicity of various pesticides. The tissue uptake of liposomal encapsulated ampicillin increased 3 to 10-fold in females as compared to male rats.
One focus of our research program is the placental transport of antiviral agents and drugs of abuse. We have examined maternal and fetal disposition of cocaine and several antiviral agents, which are used to treat HIV and HSV. A recently published study examining the interaction of AZT and Acyclovir (ACV) indicated that uptake of antiviral agents into the fetal compartment (fetus and amniotic fluid) involves a carrier mediated process as well as passive diffusion. The following figure illustrates this point. When ACV is administered in conjunction with AZT, the fetal levels of ACV are significantly higher suggesting up-regulation of transporters in the placenta.
The toxicokinetics of volatile compounds are being studied by our research group in conjunction with Drs. Bartlett and Bruckner. We are specifically examining the effect of dosing regimen (includes dose and dosing rate), age and gender on the first pass metabolism and saturation of clearance of trichloroethylene and related compounds. The dose and dosing rate significantly influence the systemic bioavailability of trichloroethylene as shown in the following graph. No detectable plasma levels of trichloroethylene were observed after administration of 10 and 50 mg/kg by gastric infusion over 2 hours. The profiles for the oral bolus doses indicate saturation of first pass metabolism and clearance of trichloroethylene.
These projects are funded in part by the Department of Energy and U.S. Agency for Toxic Substances and Disease Registry.Representative Publications
K. Srinivasan, P.P. Wang, A. Eley, C.A. White and M.G. Bartlett, Liquid Chromatography-Tandem Mass Spectrometry Analysis of Cocaine and Its Metabolites from Blood, Amniotic Fluid, Placental and Fetal Tissues: Study of the Metabolism and Distribution of Cocaine in Pregnant Rats, Journal of Chromatography B., 2000, 745(2), 287-303.
T. N. Clark, C.A. White, C.K. Chu and M.G. Bartlett, Determination of 3’-Azido-2’,3’-Dideoxyuridine(AZDU) in Maternal Plasma, Amniotic Fluid, Fetal and Placental Tissues by High Performance Liquid Chromatography, J. of Chromatography B: Biomedical Applications, 2001, 755, 165-172.
S.D. Brown, C.A. White, C.K. Chu and M.G. Bartlett, Determination of Acyclovir in Maternal Plasma, Amniotic Fluid, Fetal and Placental Tissue by High Performance Liquid Chromatography, Journal of Chromatography B: Biomedical Applications, 2002,772(2), 327-334.
S.D. Brown, M.G. Bartlett and C.A. White, Pharmacokinetics of Intravenous Acyclovir, Zidovudine and Acyclovir/Zidovudine in Pregnant Rats, Antimicrobial Agents and Chemotherapy, 2002, 47(3), 991-996.
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