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Dr. Arthur Roberts

Assistant Professor

Office: Pharmacy South, Rm 424   
Voice: 706-542-7787

Education

Ph.D. Biochemistry, Washington State University 2002

B.S. Biochemistry, University of New Mexico 1996

Research Interests

I am interested in studying the interaction of drugs with multiple-drug resistance transporters and drug-metabolizing UDP-glucuronosyltransferases.  These proteins play major roles in cancer resistance, in neurological diseases (e.g. Alzheimer’s disease and Parkinson’s) and in mitigating the effects of environmental pollutants.  Using human proteins isolated from genetically engineered yeast or bacteria, one goal is to develop structural biology tools to rapidly and accurately predict the effects of drugs and toxins before they end up in people.  These tools will allow us to design next generation drugs that are more effective and have fewer side effects than current medications.  Another goal is to develop advanced NMR and computational methods to probe the effects of drugs and toxins in whole cells.  These techniques will allow us to probe the complex interplay between transporters, receptors and enzymes during drug and metabolite processing.  In addition to these research goals, I am developing creative and novel teaching methods to train students of different skill levels in my laboratory.  Achieving these research and teaching goals will not only advance medicine and improve drug therapies, but will prepare students well for industry or academic careers in the 21st century.

Of Note

  • Best Speech Award, Toastmasters International-Stadium Chapter, San Diego, CA, 2011
  • Best Table Topics and Best Speech Awards, Toastmasters International-Stadium Chapter, San Diego, CA, 2010
  • Poster finalist, International Society for the Study of Xenobiotics (ISSX) Symposium, Maui, HI, 2005

Selected Publications

Shimshoni, J. A., Roberts, A. G., Scian, M., Topletz, A. R., Blankert, S. A., Halpert, J. R., Nelson, W. L., Isoherranen, N.  Stereoselective Formation and Metabolism of 4-Hydroxy-Retinoic Acid Enantiomers by Cytochrome P450 Enzymes. Journal of Biological Chemistry, 2012. 50. 42223-42232.

Zhao, C. Gao, Q., Roberts, A. G., Shaffer, S. A. Doneanu, C. E., Xue, S., Goodlett, D. R., Nelson, S. D., Atkins, W. M.  Cross-Linking Mass Spectrometry and Mutagenesis Confirm the Functional Importance of Surface Interactions between CYP3A4 and Holo/Apo Cytochrome b5. Biochemistry, 2012. 51. 9488-9500.

Roberts, A.G., Sjögren, S.E.A., Fomina, N., Vuc, K.T., Almutairi, A. and Halpert, J.R., NMR-Derived Models of Amidopyrine and its Metabolites Complexed to Rabbit Cytochrome P450 2B4 Reveals a Structural Mechanism of Sequential N-Dealkylation. Biochemistry, 2011. 50, 2123-2134.

Roberts, A. G., Cheesman, M. J., Primak, A., Bowman, M. K., Atkins, W. M., and Rettie, A. E. Intramolecular Heme Ligation of the Cytochrome P450 2C9 R108H Mutant Demonstrates Pronounced Conformational Flexibility of the B-C Loop Region: Implications for Substrate Binding, Biochemistry, 2010. 49, 8700-8708.

Gay, S. C, Roberts, A. G., and Halpert, J. R. Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR, Future Medicinal Chemistry, 2010. 2, 1451-1468.

Gay, S. C., Roberts, A. G., Maekawa, K., Talakad, J. C., Hong, W. X., Zhang, Q., Stout, C. D., and Halpert, J. R. Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel, Biochemistry, 2010. 49, 8709-8720.

Wilderman, P. R., Shah, M. B., Liu, T., Li, S., Hsu, S., Roberts, A. G., Goodlett, D. R., Zhang, Q., Woods, V. L., Jr., Stout, C. D., and Halpert, J. R. Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-Ray crystallography, Journal of Biological Chemistry, 2010. 49, 38602-38611.

Affiliations