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Dr. Dexi Liu

Department Head

Panoz Professor of Pharmacy

Office: Pharmacy South, Rm 450   
Voice: 706-542-7385

Education

Ph.D. Biochemistry, University of Tennessee 1990

B.S. Biochemistry and Microbiology, Lanzhou University, Lanzhou, PR China 1982

Research Interests

My laboratory is interested in the use of gene/protein as a drug for prevention and treatment of obesity, diabetes, cancer and other diseases. Our emphasis is on identification of genes that code for a therapeutic protein and on illustration of its mechanisms of action. We employ gene cloning, biochemical, cell biological, immunological, and gene delivery/transfer techniques to conduct basic research in cell culture and in animal models. 

Grant Support

  • National Institute of Biomedical Imaging and Bioengineering  
  • National Heart, Lung, and Blood Institute

Of Note

  • Deputy Editor: Molecular Therapy 
  • Associate Editor: AAPS Journal
  • Editorial Board Member: Molecular Therapy - Nucleic Acids; Molecular Therapy – Methods & Clinical Development; Pharmaceutical Research

Selected Publications

2015

Yongjie Ma, Mingming Gao, Hao Sun, Dexi Liu (2015) Interleukin-6 gene transfer reverses body weight gain and fatty liver in obese mice. BBA - Molecular Basis of Disease. http://dx.doi.org/10.1016/j.bbadis.2015.01.01

Mingming Gao, Yongjie Ma and Dexi Liu (2015) High-fat diet-induced adiposity, adipose inflammation, hepatic steatosis and hyperinsulinemia in outbred CD-1 mice. PLoS ONE. 10(3): e0119784. doi:10.1371/journal.pone.0119784

Mingming Gao, Yongjie Ma, Chunbo Zhang and Dexi Liu (2015) Cold exposure improves the anti-diabetic effect of T0901317 in streptozotocin-induced diabetic mice. AAPS J. http://link.springer.com/article/10.1208%2Fs12248-015-9746-4

AlSaggar, M. & Dexi Liu (2015). Physical methods for gene transfer. In L. Huang, D. Liu, & E. Wagner (Eds.), Non-Viral Vectors for Gene Therapy: Physical Methods and Medical Translation (pp. 1–24).

Suda, T. & Dexi Liu (2015). Hydrodynamic delivery. In L. Huang, D. Liu, & E. Wagner (Eds.), Non-Viral Vectors for Gene Therapy: Physical Methods and Medical Translation (pp. 89–111).

Yahya Alhamhoom, Mohammed Alsaggar and Dexi Liu (2015) Future Perspective Toward Targeting at the Cellular Level. In Advances and Challenges in the Development of Oligonucleotide-based Therapies, Future Science eBook. In press.

Kenya Kamimura, Takishi Suda, and Dexi Liu (2015) Hydrodynamic delivery. In Advances and Challenges in the Development of Oligonucleotide-based Therapies, Future Science eBook. In press.

Kenya Kamimura, Hiroyuki Abe, Yuji Kobayashi, Takeshi Suda, Yutaka Aoyagi, Dexi Liu (2015) Image-guided hydrodynamic gene delivery to liver: toward clinical applications. In “Gene Therapy and Cell Therapy through the Liver” Edited by Shuji Terai and Takeshi Suda, Springer Japan KK, Tokyo, Japan. In press.

Mohammad Alsaggar and Dexi Liu (2015) Liver-Targeted Gene and Cell Therapy - An Overview. In “Gene Therapy and Cell Therapy through the Liver” Edited by Shuji Terai and Takeshi Suda, Springer Japan KK, Tokyo, Japan. In press.

2014

Mingming Gao, Yongjie Ma, Ran Cui and Dexi Liu (2014) Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet, J Controlled Release 185:1-11.

Ran Cui, Mingming Gao, Shen Qu and Dexi Liu (2014) Overexpression of superoxide dismutase 3 gene blocks high-fat diet-induced obesity, fatty liver and insulin resistance. Gene Ther 21:840-848.

Tsutomu Kanefuji, Takeshi Yokoo, Takeshi Suda, Hiroyuki Abe, Kenya Kamimura, Yutaka Aoyagi and Dexi Liu (2014) Hemodynamics of a hydrodynamic injection. Mol Ther - Meth & Clinic Develop doi:10.1038/mtm.2014.29

Mingming Gao and Dexi Liu (2014) Gene therapy for obesity: progress and prospects. Discov Med 17:319-328.

Kenya Kamimura, Tsutomu Kanefuji, Takeshi Yokoo, Hiroyuki Abe, Takeshi Suda, Yuji Kobayashi, Guisheng Zhang, Yutaka Aoyagi and Dexi Liu (2014) Safety assessment of liver-targeted hydrodynamic gene delivery in dogs. PLoS ONE 9(9): e107203. doi:10.1371/journal.pone.0107203

Yongjie Ma, Mingming Gao and Dexi Liu (2014) Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice. Pharm Res doi: 10.1007/sI 1095-014-1526-9.

Hao Song and Dexi Liu (2014) Hydrodynamic delivery of interleukin-15 gene promotes resistance to high fat diet-induced obesity, fatty liver and improves glucose homeostasis. Gene Ther In press

Mohammad AlSaggar and Dexi Liu (2014) Gene delivery: an essential component for successful gene therapy. In  "Drug Delivery", Edited by Ashim Mitra, Deep Kwatra, and Aswani Dutt Vadlapudi, Jones & Bartlett Learning, Burlington, MA, USA, pp 381-398.

2013

Mingming Gao, Chunbo Zhang, Yongjie Ma, Le Bu, Linna Yan and Dexi Liu (2013) Hydrodynamic delivery of mIL10 gene protects mice from high fat diet-induced obesity andglucose intolerance. Mol Ther21:1852-1861.

Le Bu, Mingming Gao, Shen Qu and Dexi Liu (2013) Intraperitoneal injection of clodronate liposomes eliminates visceral adipose macrophages and blocks high-fat diet-induced weight gain and development of insulin resistance. AAPS J 15:1001-1011.

Mingming Gao, Yongjie Ma and Dexi Liu (2013) Rutin suppresses palmitic acids-triggered inflammation in macrophages and blocks high fat diet-induced obesity and fatty liver in mice. Pharm Res, 30:2940-2950.

Mingming Gao, Le Bu, Yongjie Ma and Dexi Liu  (2013) Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice. PLoS ONE 8: e65641.doi:10.1371/journal.pone.0065641  

Mingming Gao and Dexi Liu (2013) The liver X receptor agonist T0901317 protects mice from high fat diet induced obesity and insulin resistance. AAPS J 15:258-266.

Kenya Kamimura, Takeshi Suda, Guisheng Zhang, Yuji Aoyagi, and Dexi Liu (2013) Parameters affecting image-guided, hydrodynamic gene delivery to swine liver. Mol Ther Nucleid Acids. doi: 10.1038/mtna.2013.52.

Mingming Gao and Dexi Liu (2013) Resveratrol suppresses T0901317-induced hepatic fat accumulation in mice. AAPS J 15:744-752.

Yongjie Ma, Yixian Huang, Linna Yan, Mingming Gao and Dexi Liu (2013) Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance. Pharm Res 30:1447-1457.

Yongjie Ma and Dexi Liu (2013) Hydrodynamic delivery of adiponectin and adiponectin receptor 2gene blocks high-fat diet-induced obesity and insulin resistance. Gene Ther 20:846-852.

Kenya Kamimura, Takeshi Suda, Yutaka Aoyagi and Dexi Liu (2013) Liver-directed gene therapy. JSM Gastroenterology and Hepatology 1(1):1005.

Affiliations

Current Graduate Students