University of Georgia Pharmaceutical and Biomedical Sciences

Ph.D. Toxicology, University of Michigan 1974

M.S. Toxicology, University of Texas 1971

B.S. Pharmacy, University of Texas 1968

Dr. Bruckner’s main focus of ongoing research is on basic toxicology and pharmacokinetic questions that impact assessments of risks of chemicals to human health. The Bruckner lab is currently focused on volatile organic chemicals (VOCs) and pesticides. High lifetime doses of VOCs cause cancer in mice and rats, but it is unclear whether low environmental exposures pose a cancer risk to humans. Animal studies are being conducted to determine the effectiveness of detoxification presystemic elimination and other protective mechanisms against trace-level exposures. Studies are also conducted to learn whether drug-chemical interactions are of consequence under these conditions. Work is underway to develop physiologically-based pharmacokinetic models for predicting risks of pyrethroid pesticides to children’s health. Grants from the EPA, DOE and CDC support these activities.

• Pyrethroid Working Group (PWG)

• Korean Society of Toxicology International Symposium in Seoul, Invited speaker for opening presentation, 2011

Bruckner, J.V., Osmitiz, T.G., Anand, S., Minnema, D., Schmitt, W., Assaf, N., and Zastre, J.:   The influence of maturation on rat and human physiological processes involving protein and lipoprotein binding, gastrointestinal absorption, and blood brain barrier permeability and transport of pyrethroids.  Pest. QSAR and PBPK/PD Models for Human Risk Assessment, ACS Symposium  Series (2012).

Bruckner, J.V., Anand, S.S., and Warren, D.A.:   Toxic effects of solvents and vapors.  Ch. 24, in Casarette and Doull’s Toxicology: The Basic Science of Poisons, (Klaassen, C.D., ed.), 8^th edition, McGraw-Hill, New York (2012).

Bruckner, J.V., White, C.A., Muralidhara, S., and Dallas, C.E.:   Effect of exposure route and dosage regimen on the toxicokinetics and target organ toxicity of 1,1-dichloroethylene. J. Pharmacol. Exp. Therap.  333: 519-527 (2010).

Kim, K.-B., Anand, S.S., Kim, H.J., White, C.A., Fisher, J.W., Tornero-Velez, R. and Bruckner, J.V.:   Age-, dose- and time-dependency of plasma and tissue distribution of deltamethrin in immature rats.  Toxicol. Sci. 110: 354-368 (2010).

Tornero-Velez, R., Mirfazaelian, A., Kim, K.-B., Anand, S.S., Kim, H.J., Haines, W.T., Bruckner, J.V., and Fisher, J.W.:   Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model.  Toxicol. Appl. Pharmacol. 244: 208-217 (2010).

Bruckner, J.V.:   Studies in Humans - Regulation of Pesticides and Other Chemicals by the EPA.  Ch. 59 in Hayes Handbook of Pesticide Toxicology (Krieger, R., ed.), 3^rd edition, Vol. II, Elsevier, Amsterdam (2010).

Bruckner, J.V.:   Adverse effects of occupational and environmental chemicals on the male reproductive system.  Submitted to Crit. Rev. Toxicol. (2011).

• Society of Toxicology, Biological Modeling Specialty, President
• FIFRA Scientific Advisory Board (SAB), Member
• Committee on Toxicology, Member
• Board on Environmental Studies and Toxicology, Member
• National Academy of Sciences, Member
• ACGIH Threshold Limit Value (TLV) Chemical Substances Committee, Member
• New York Academy of Sciences, Member
• American Association for the Advancement of Science, Member
• American Society for Pharmacology and Experimental Therapeutics (ASPET), Member
• American Conference of Governmental Industrial Hygienists (ACGIH), Member