Dr. Aaron Beedle


Assistant Professor

Office: Pharmacy South, Rm 340
Voice: 706-542-6422
Dr. Aaron Beedle

Education

Ph.D. Neuroscience, University of Calgary, Alberta, Canada 2003

B.Sc.H Life Science, Queen’s University, Ontario, Canada 1998

Research Interests

Dr. Beedle’s laboratory studies the biology and disease of the dystrophin-glycoprotein complex. This complex is an important structural link between the intracellular cytoskeleton and the extracellular matrix. Dystroglycan, a primary component of the complex, undergoes extensive glycosylation of its protein core. If these glycans are disrupted, dystroglycan can no longer bind to the extracellular matrix and muscular dystrophy develops affecting a range of tissues including skeletal and cardiac muscle, brain, and eye. In her lab, Dr. Beedle’s group uses genetically modified mice, cell culture and molecular biology to study dystroglycan disease mechanisms, processing enzymes, and therapeutic strategies. Techniques such as conditional gene knockout strategies, animal physiology, biochemistry, genetics, molecular biology, cell culture and histology are used.

Grant Support

  • CoPI, Pilot Project: “Lineage-Specific Glycan Expression and Function in Muscular Dystrophies and Congenital Disorders of Glycosylation”.  Funded by the NIGMS UGA Pluripotent Stem Cell Program Project grant.
  • Co-Investigator, R03: “Elucidating mitochondrial pathomechanisms of ENT3 disorders in ENT3 KO mice”. Funded by the National Institutes of Health (NIAMS). Raj Govindarajan, P.I. 2013-2016
  • Principal Investigator, R15: “Elucidating muscle regeneration/differentiation defects in fukutin KO mice”. Funded by the National Institutes of Health (NIAMS). 2014-2017
  • Co-Investigator, R01: “Structure and function of alpha-dystroglycan glycosylation”. Funded by the National Institutes of Health (NIGMS). David Live, P.I. 2014-2018

Of Note

  • Teacher of the Week, UGA Center for Teaching and Learning, Spring 2015  Teacher of the Week – A. Beedle
  • Lilly Teaching Fellow, University of Georgia 2012-2014
  • Disease Models and Mechanisms Interdisciplinary Group Founder and Coordinator, UGA ILS Graduate Program, 2013
  • Muscular Dystrophy Association Development Grant Awardee, 2008-2010
  • Postdoctoral Teaching Award (Inagural), Department of Molecular Physiology and Biophysics, University of Iowa, 2009
  • Alberta Heritage Foundation for Medical Research Fellow, 2003-2006
  • Peter A. Getting Postdoctoral Scholar Award, Department of Physiology and Biophysics, University of Iowa, 2003-2006

Selected Publications

Foltz SJ, Luan J, Call JA, Patel A, Peissig KB, Fortunato MJ and Beedle AM* (2016) Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy.  Skeletal Muscle 6:20. doi: 10.1186/s13395-016-0091-9

Nichenko AS, Southern WM, Atuan M, Luan J, Peissig KB, Foltz JS, Beedle AM, Warren GL and Call JA (2016) Mitochondrial maintenance via autophagy contributes to functional skeletal muscle regeneration and remodeling. Am J Physiol Cell Physiol. Jun 8:ajpcell.00066.2016. doi: 10.1152/ajpcell.00066.2016. [Epub ahead of print]

Foltz SJ, Modi JN, Melick GA, Abousaud MI, Luan J, Fortunato MJ, Beedle AM (2016) Abnormal Skeletal Muscle Regeneration plus Mild Alterations in Mature Fiber Type Specification in Fktn-Deficient Dystroglycanopathy Muscular Dystrophy Mice. PLoS ONE 11(1): e0147049. doi:10.1371/journal.pone.0147049 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147049

Fortunato MJ, Ball CE, Hollinger K, Patel NB, Modi JN, Rajasekaran V, Nonneman DJ, Ross JW, Kennedy EJ, Selsby JT and Beedle AM* (2014) Development of rabbit monoclonal antibodies for detection of alpha-dystroglycan in normal and dystrophic tissue.  PLoS ONE 9(5): e97567. Doi:10.1371/journal.pone.0097567.

Beedle AM, Turner AJ, Saito Y, Lueck JD, Foltz SJ, Fortunato MJ, Nienaber PM and Campbell KP (2012) Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy. J. Clin. Inv. 122(9):3330-3342. doi:10.1172/JCI63004.

Noell S, Wolburg-Buchholz K, Mack AF, Beedle AM, Satz JS, Campbell KP, Wolburg H and Fallier-Becker P (2011) Expression pattern and distribution of aquaporin-4 in the GFAP-cre/Dystroglycan null mouse brain. Eur. J. Neurosci. 33:2179-86.

Uriu Y, Kiyonaka S, Miki T, Yagi M, Akiyama S, Mori E, Beedle AM, Campbell KP, Wakamori M and Mori Y (2010) Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long-lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels. J. Biol. Chem. 285:21750-67.

Beedle AM, Nienaber PM and Campbell KP (2007) Fukutin-related protein associates with the sarcolemmal dystrophin-glycoprotein complex. J. Biol. Chem. 282(23):16713-16717.

Kiyonaka S, Wakamori M, Miki T, Uriu Y, Nonaka M, Bito H, Beedle AM, Mori E, Hara Y, De Waard M, Kanagawa M, Itakura M, Takahashi M, Campbell KP and Mori Y (2007) RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+channels. Nat. Neurosci.10(6):691-701.

Altier C, Khosravani H, Evans RM, Hameed S, Peloquin JB, Vartian BA, Chen L, Beedle AM, Ferguson SS, Mezghrani A, Dubel SJ, Bourinet E, McRory JE and Zamponi GW (2006) ORL1 receptor-mediated internalization of N-type calcium channels. Nat. Neurosci. 9(1):31-40.

Beedle AM, McRory JE, Poirot O, Doering CJ, Altier C, Barrere C, Hamid J, Nargeot J, Bourinet E and Zamponi GW (2004) Agonist independent modulation of N-type calcium channels by ORL1 receptors.  Nat. Neurosci. 7(2):118-125.

Beedle AM and Zamponi GW (2003) Modulation of high voltage-activated calcium channels by G protein-coupled receptors. In Calcium channel pharmacology, ed. Stefan McDonough (Kluwer Academic/Plenum Publishing, ISBN 0-306-474878-1).  420 pp.

Beedle AM, Hamid J and Zamponi GW (2002) Inhibition of transiently expressed low- and high-voltage-activated calcium channels by trivalent metal cations.  J. Mem. Biol. 187:225-238.

Beedle AM and Zamponi GW (2000) Block of voltage-dependent calcium channels by aliphatic monoamines.  Biophys. J. 79:260-270.

See more publications for Dr. Beedle at NCBI.

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