Dr. David Chu

Distinguished Research Professor, Emeritus

Office: Wilson Pharmacy, Rm 374   
Voice: 706-542-5379
david chu


Ph.D. Medicinal Chemistry, State University of New York 1974

M.S. Medicinal Chemistry, Idaho State University 1970

B.S. Pharmacy, Seoul National University 1964

Research Interests

Dr. Chu’s research focuses on nucleoside and carbohydrate chemistry, antiviral chemotherapy (HIV, Hepatitis B & C, West Nile and Epstein-Barr), cancer chemotherapy, structure-based drug design and molecular modeling, and antiviral drug discovery for bioterrorism (Smallpox, Monkeypox, Ebola, etc.).

Of Note

  • Florida A&M University College of Pharmacy RCMI, National Board Member, 2002-Present
  • Elected Fellow of American Association of Advancement of Science, 2002
  • Inventor of the Year Award, UGA, 2002
  • NIH Advisory Committee Member, 1987-2002
  • NIH Merit Award, 2001-2011
  • Marquis Who’s Who in America
  • Marquis Who’s Who in the World

Selected Publications

Singh, U.; Mishera, R.C.; Shanka R.;  Chu C.K.; Stereoselective Synthesis of 2’-fluoro-6’-methylene carbocyclic adenosine via Vince Lactam, J. Org. Chem., 2014, 79, 3917-3923.

Chandra De; Liu, D.; Zheng, B.; Singh, U.S.; Chavre, S.; White, C.; Arnold R. D.; Hagen, F.K.; Chu, C.K.;Moffat, J.J. b–L-1-{5-(E-2-Bromovinyl)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)]uracil (L-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism, Antiviral Research, 110, 10-19, 2014.

Al Sarjalani, O.N.; Rais, R.H.; Kim, Y.A.; Chu, C.K.; Naguib, F.N.M.; el Kouni, M.H. Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: Biological activities and selective toxicities, Biochem. Pharmacol. 2010, 80, 955-963.

Gadthula, S.; Rawal, R.K.; Sharon, A.; Wu, D.; Korba, B.; Chu, C.K. Synthesis and antiviral activity of cyclopropyl spirocarbocyclic adenosine,  (4R,5S,6R, 7R)-4-(6-amino-9H-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,5-diol against hepatitis C virus, Bioorg. Med. Chem. Lttrs., 2011, 3982-3985

Rowe, J.; Arnold, R.D.; Zhang, B.; White, C.; Toli, J.; Chu, C.K.; Moffat, J.F. b–L-1-{5-(E-2-Bromovinyl)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)]uracil (L-BHDU) prevents varicella-zoster virus replication in fibroblasts, skin organ culture and SCID-Hu mice with human skin xenogafts, Antiviral Research, 2011, in press.

Wang, J.N.; Rawal, R.; C.K.Chu in Recent advances in carbocyclic nucleosides:Synthesis and Biological Activity in Medicinal Chemistry of Nucleic Acid, Zhang eds. Wiley, 2011.

Wang, J; Singh, U.S.; Rawal, R. K.; Chavre S. N.; Sugiyama,M.; Woo,D.; Yoo,J.; Jha, A.K.; Scroggin,M.; Huang,Z.; Murray,M.G.; Govindarajan,R.;Tanaka,Y.;Korba,B.; and Chu, C.K. Antiviral Activity of Novel 2′-Fluoro-6′-methylene-carbocyclic adenosine (FMCA) and its Monophosphate Prodrug (FMCAP) Against Wild-type and Drug-resistant Hepatitis B Virus Mutants,. 2011, Bioorg. Med. Chem. Lttrs. In press.

Rawal, R.K.; Singh, U.S.; Gadthula,S.; Chu, C.K., Synthesis of Entecavir and its Novel Class  of     Analogues, Current Protocol. 2011.