Ph.D. Toxicology, University of Michigan 1974
M.S. Toxicology, University of Texas 1971
B.S. Pharmacy, University of Texas 1968
Dr. Bruckner’s main focus of ongoing research is on basic toxicology and pharmacokinetic questions that impact assessments of risks of chemicals to human health. The Bruckner lab is currently focused on volatile organic chemicals (VOCs) and pesticides. High lifetime doses of VOCs cause cancer in mice and rats, but it is unclear whether low environmental exposures pose a cancer risk to humans. Animal studies are being conducted to determine the effectiveness of detoxification presystemic elimination and other protective mechanisms against trace-level exposures. Studies are also conducted to learn whether drug-chemical interactions are of consequence under these conditions. Work is underway to develop physiologically-based pharmacokinetic models for predicting risks of pyrethroid pesticides to children’s health. Grants from the EPA, DOE and CDC support these activities.
Pyrethroid Working Group (PWG)
Korean Society of Toxicology International Symposium in Seoul, Invited speaker for opening presentation, 2011
Sethi, P.K., White, C.A., Cummings, B.S., Hines, R.N., Muralidhara, S., and Bruckner, J.V.: Ontogeny of plasma proteins, albumin and binding of diazepam, cyclosporin and deltamethrin. (2016). Pediatr. Res. 79: 409-415. doi: 10.1038/pr.2015.237.
Bruckner, J.V. Organic solvents. Ch. 11, in Mammalian Toxicology (Abou-Donia, M.B., ed.), 1st edition, Wiley and Sons, Ltd., New York (2015).
Darren Gullick, Andrew Popovici, Holly C. Young, James V. Bruckner, Brian S. Cummings, Pei Li and Michael G. Bartlett. (2014). Determination of deltamethrin in rat plasma and brain tissue using gas chromatography-negative chemical ionization mass spectrometry. Journal of Chromatography B, 960, 158-165.
Sethi, P.K., Muralidhara, S., Bruckner, J.V., and White, C.A. (2014). Measurement of plasma protein and lipoprotein binding of pyrethroids. J. Pharmacol. Toxicol. Methods 70: 106-111.
Zastre, J., Dowd, C., Bruckner, J.V., and Popovici, A. Lack of P-glycoprotein mediated efflux and the potential involvement of an influx transport process contributing to the intestinal uptake of deltamethrin, cis-permethrin, and transpermethrin. (2013). Toxicol. Sci. 136: 284-293.
Bruckner, J.V., Anand, S.S., and Warren, D.A.: Toxic effects of solvents and vapors. Ch. 24, in Casarette and Doull’s Toxicology: The Basic Science of Poisons, (Klaassen, C.D., ed.), 8th edition, McGraw-Hill, New York (2013).
Bruckner, J.V., Osmitiz, T.G., Anand, S., Minnema, D., Schmitt, W., Assaf, N., and Zastre, J. The influence of maturation on rat and human physiological processes involving protein and lipoprotein binding, gastrointestinal absorption, and blood brain barrier permeability and transport of pyrethroids. Pest. QSAR and PBPK/PD Models for Human Risk Assessment, ACS Symposium Series (2012).
Bruckner, J.V., White, C.A., Muralidhara, S., and Dallas, C.E. Effect of exposure route and dosage regimen on the toxicokinetics and target organ toxicity of 1,1-dichloroethylene. J. Pharmacol. Exp. Therap. 333: 519-527 (2010).
Kim, K.-B., Anand, S.S., Kim, H.J., White, C.A., Fisher, J.W., Tornero-Velez, R. and Bruckner, J.V. Age-, dose- and time-dependency of plasma and tissue distribution of deltamethrin in immature rats. Toxicol. Sci. 110: 354-368 (2010).
Tornero-Velez, R., Mirfazaelian, A., Kim, K.-B., Anand, S.S., Kim, H.J., Haines, W.T., Bruckner, J.V., and Fisher, J.W. Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model. Toxicol. Appl. Pharmacol. 244: 208-217 (2010).
Bruckner, J.V. Studies in Humans – Regulation of Pesticides and Other Chemicals by the EPA. Ch. 59 in Hayes Handbook of Pesticide Toxicology (Krieger, R., ed.), 3rd edition, Vol. II, Elsevier, Amsterdam (2010).
- Society of Toxicology, Biological Modeling Specialty, President
- FIFRA Scientific Advisory Board (SAB), Member
- Committee on Toxicology, Member
- Board on Environmental Studies and Toxicology, Member
- National Academy of Sciences, Member
- ACGIH Threshold Limit Value (TLV) Chemical Substances Committee, Member
- New York Academy of Sciences, Member
- American Association for the Advancement of Science, Member
- American Society for Pharmacology and Experimental Therapeutics (ASPET), Member
- American Conference of Governmental Industrial Hygienists (ACGIH), Member