Dr. Michael G. Bartlett


Professor and Director-BS Program

Georgia Athletic Association Professor in Pharmacy

Interim Assistant Dean for Nontraditional Education and Outreach

Office: Wilson Pharmacy, Rm 420
Voice: 706-542-5390
Find out about the BS Program
michael g. bartlett

Education

Ph.D. Analytical Chemistry, Georgia Institute of Technology 1994

B.S. Chemistry, North Carolina State University 1990

Research Interests

Dr. Bartlett’s lab research centers around applications of analytical chemistry to study biological problems. Currently, he and his team are studying the absorption, distribution, metabolism and excretion (ADME) of drug substances and environmental toxicants with the goal of developing novel methods to address significant questions in the biomedical sciences. In collaboration with Dr. James Bruckner, they aim to provide realistic risk assessments for common environmental contaminants. Furthermore, in collaboration with Dr. Alvin V. Terry at the Medical College of Georgia (MCG), they also study many compounds shown to affect memory and cognition, and have developed several highly sensitive assessments to determine overall impact on the brain.

Grant Support

  • Council for the Advancement of Pyrethroid Human Risk Assessment
  • National Institutes for Health (R21 AA021948)
  • National Institutes for Health (R01 CA172495)
  • National Institutes for Health (R15 CA176653)
  • American Cancer Society

Of Note

  • 2013 Outstanding Manuscript in Analysis and Pharmaceutical Quality from the American Association for Pharmaceutical Scientists
  • 2011 Elected Fellow of the American Association for Pharmaceutical Scientists
  • Research Achievement Award in Analysis and Pharmaceutical Quality from the American Association for Pharmaceutical Scientists, 2010
  • Certificate of Appreciation, Alfred P. Sloan Foundation, Advancing Underrepresented Minority Students in STEM Disciplines, 2007
  • G.E. Philbrook Award for Undergraduate Teaching, Northeast Georgia Chapter of the American Chemical Society, 2005

Selected Publications

Babak Basiri, J. Michael Sutton, Brad S. Hanberry, Jason A. Zastre and Michael G. Bartlett*, “Ion-pairing liquid chromatography method for the determination of thiamine homeostasis.” Biomedical Chromatography, 30, 35-41 (2016).; doi: 10.1002/bmc.3544

Shirin Hooshfar, Babak Basiri and Michael G. Bartlett*, “Development of a surrogate matrix for cerebral spinal fluid for LC/MS based analytical methods.” Rapid Communications in Mass Spectrometry, 30, 854-858 (2016).; doi: 10.1002/rcm.7509

Darren R. Gullick, James V. Bruckner, Catherine A. White, Chen Chen, Brian S. Cummings and Michael G. Bartlett*, “Quantitation of deltamethrin in rat liver and muscle homogenates using dispersive solid phase extraction and gas chromatography-negative chemical ionization mass spectrometry.” Journal of the AOAC International, 99, 813-820 (2016).; doi: 10.5740/jaoacint.15-0314

Jaeah Kim, Christopher P. Hopper, Kelsey H. Connell, Parisa Darkhal, Jason A. Zastre and Michael G. Bartlett*, “Development of a novel method for the bioanalysis of benfotiamine and salbutiamine for the determination of their impact on cancer cell proliferation.” Analytical Methods, 8, 5596-5603 (2016).; doi: 10.1039/c6ay01387b

Xiangkun Yang and Michael G. Bartlett* (2016), “Identification of protein adduction using mass spectrometry: Protein adducts as biomarkers and predictors of toxicity mechanisms.” Rapid Communications in Mass Spectrometry, 30, 652-664.; doi: 10.1002/rcm.7462

Darren R. Gullick, Kyle B. Mott and Michael G. Bartlett*, “Chromatographic methods for the bioanalysis of pyrethroid pesticides.” Biomedical Chromatography, 30, 772-789 (2016).; doi: 10/1002/bmc.3712

Pei Li, Wayne D. Beck, Patrick M. Callahan, Alvin V. Terry and Michael G. Bartlett, “Pharmacokinetics of cotinine in rats: a potential therapeutic agent for disorders of cognitive function.” Pharmacological Reports, 67, 494-500 (2015).

Pei Li, Zi Li, Wayne D. Beck, Patrick M. Callahan, Alvin V. Terry, Maor Bar-peled and Michael G. Bartlett, “Biogeneration of stable isotope-labeled internal standards for absolute and relative quantitation of phase II drug metabolites using LC-MS/MS” Analytical and Bioanalytical Chemistry, 407, 4053-4063 (2015).

Xisheng Yan, Dylan W. Maixner, Ruchi Yadav, Mei Gao, Pei Li, Michael G. Bartlett and Han-rong Weng, “Paclitaxel induces acute pain via directly activating spinal TLR4” Molecular Pain, 11, 10 (2015).

Xiangkun Yang, Indrani Poddar, Caterina M. Hernandez, Alvin V. Terry, Michael G. Bartlett, “Simultaneous quantitation of quetiapine and its active metabolite norquetiapine in rat plasma and brain tissue by high performance liquid chromatography / electrospray ionization tandem mass spectrometry (LC-MS/MS).” Journal of Chromatography B, 1002, 71-77 (2015).

Buyun Chen, Guanhua Chen, Michael G. Bartlett (2014) “Factors influencing the electrokinetic injection of oligonucleotides in capillary gel electrophoresis when using laser induced fluorescence detection.” Biomedical Chromatography, 28, 320-323.

Darren Gullick, Andrew Popovici, Holly C. Young, James V. Bruckner, Brian S. Cummings, Pei Li and Michael G. Bartlett (2014) “Determination of deltamethrin in rat plasma and brain tissue using gas chromatography-negative chemical ionization mass spectrometry.”Journal of Chromatography B, 960, 158-165.

Babak Basiri and Michael G. Bartlett, (2014) “Liquid chromatography mass spectrometry of oligonucleotides: Applications in biomedical research.”  Bioanalysis, 6, 1525-1542.

Pei Li and Michael G. Bartlett (2014) “A review of quantitative methods for small molecules in brain tissue by liquid chromatography tandem mass spectrometry.” Analytical Methods, 6, 6183-6207.

B. Chen, S.F. Mason and M.G. Bartlett, “The Effect of Organic Modifiers on the Electrospray Ionization Charge-State Distribution and Desorption Efficiency for Oligonucleotides.” Journal of the American Society for Mass Spectrometry, 24, 257-264 (2013).

B. Chen and M.G. Bartlett, “Evaluation of mobile phase composition for enhancing sensitivity of targeted quantification of oligonucleotides using ultra-high performance liquid chromatography and mass spectrometry (UHPLC-MS/MS): Application to phosphorothioate DNA.” Journal of Chromatography A, 1288, 73-81 (2013).

J.A. Zastre, B.S. Hanberry, R.L. Sweet, A.C. McGinnis, K.R. Venuti, M.G. Bartlett and R. Govindarajan, “Up-regulation of Vitamin B1 Homeostasis Genes in Breast Cancer.”Journal of Nutritional Biochemistry, 24, 1616-1624 (2013).

P. Li, B.J. Albrecht, X. Yan, M. Gao, H-R. Weng, M.G. Bartlett, “A rapid analytical method for the quantification of paclitaxel in rat plasma and brain tissue using high performance liquid chromatography tandem mass spectrometry.”  Rapid Communications in Mass Spectrometry, 27, 2127-2134 (2013).

A.C. McGinnis, B.S. Cummings and M.G. Bartlett, “Ion exchange liquid chromatography method for the direct determination of small ribonucleic acids.”  Analytica Chimica Acta, 799, 57-67 (2013).

A.C. McGinnis, E.C Grubb and M.G. Bartlett, “Systematic optimization of ion-pairing agents and hexafluoroisoproponal for enhanced electrospray ionization mass spectrometry of oligonucleotides.” Rapid Communications in Mass Spectrometry, 27, 2655-2664 (2013).

M.G. Bartlett, B. Chen, A.C. McGinnis, Chapter 48: Liquid Chromatography Mass Spectrometric Bioanalysis of Oligonucleotides; In The Handbook of LC-MS Bioanalysis; Wiley-Blackwell, November 2013, ISBN: 9781118159248.

A.C. McGinnis, B. Chen and M.G. Bartlett, “Chromatographic Methods for the Determination of Therapeutic Oligonucleotides.”  Journal of Chromatography B, 883-884, 76-94 (2012).

A.V. Terry, J.J. Buccafusco, R. Schade, L. Vandenhuerk, P.M. Callahan, W.D. Beck, E.J. Hutchings, J.M. Chapman, P. Li and M.G. Bartlett, “The Nicotine Metabolite, Cotinine, Attenuates Glutamate (NMDA) Antagonist-related Effects on the Performance of the Five Choice Serial Reaction Time Task (5C-SRTT) in Rats.” Biochemical Pharmacology, 83, 941-951 (2012).

B. Chen and M.G. Bartlett, “Determination of Therapeutic Oligonucleotides Using Capillary Electrophoresis.”  Biomedical Chromatography, 26, 409-418 (2012).

F. Liang, A.V. Terry and M.G. Bartlett, “Determination of Aripiprazole in Rat Plasma and Brain Using Ultra Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry.”  Biomedical Chromatography, 26, 1325-1332 (2012).

P. Li, W.D. Beck, P.M. Callahan, A.V. Terry and M.G. Bartlett, “Quantitation of Cotinine and its Metabolites by Hydrophilic Interaction Chromatography Tandem Mass Spectrometry.”Journal of Chromatography B, 907, 117-125 (2012).

B. Chen and M.G. Bartlett, “A One Step Solid Phase Extraction Method for the Bioanalysis of a Phosphorothioate Oligonucleotide and its 3’ n-1 Metabolite From Plasma Using UHPLC-MS/MS.”  AAPS Journal, 14, 772-780 (2012).

H. Yi, H-J. Cho, S-M. Cho, D-G. Lee, A.M. Abd El-Aty, S-J. Yoon, G-W. Bae, K. Nho, B. Kim, C-H. Lee, J-S. Kim, M.G. Bartlett and H-C. Shin*, “Pharmacokinetic Properties and Anti-tumor Efficacy of a 5-Fluorouracil Loaded PEG-Hyrdogel.” BMC Cancer, 10, 211 (2010).

A.V. Terry*, D.A. Gearhart, A. Pillai, G. Zhang and M.G. Bartlett, “Chronic antipsychotic treatment: protracted decreases in phosphor-TrkA nerve growth factor receptor levels in the rat hippocampus.” International Journal of Neuropsychopharmacology, 13, 799-805 (2010).

M.K. Altman, V. Gopal, W. Jia, S. Yu, H. Hall, G.B. Mills, C. McGinnis, M.G. Bartlett, G. Jiang, D. Madan, G.D. Prestwich, Y. Xu, M.A. Davies and M.M. Murph*, “Targeting Melanoma Growth and Viability Reveals Dualistic Functionality of the Phosphonothioate Analogue of Carba Cyclic Phosphatidic Acid.” Molecular Cancer, 9, 140 (2010).

H. Yi, M-J. Shin, S-M. Cho, D-G. Lee, K. Cho, H-J. Cho, S-J Shin, M.G. Bartlett, J-S. Kim and H-C. Shin*, “Nonlinear Toxicokinetics of Enrofloxacin in Rats.” Archives of Pharmaceutical Research, 33(11), 1851-1857 (2010).

A.V. Terry*, J.J. Buccafusco, D.A. Gearhart, W.D. Beck, M-L. Middlemore, J.N. Truan, G.M. Schwarz, M. Xu, M.G. Bartlett, A. Kutiyanawallaa, A. Pillai, “Repeated, Intermittent Exposures to Diisopropylfluorophosphate in Rats: Protracted Effects on Nerve Growth Factor-Related Proteins, Cholinergic Markers, and Cognitive Function.” Neuroscience,176, 237-253 (2011).

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