Dr. Raj Govindarajans


Associate Professor

Office: Wilson Pharmacy, Rm 234A   
Voice: 706-542-5759
raj govindarajan

Dr. Raj Govindarajan

Ph.D. Biochemistry and Molecular Biology, University of Nebraska Medical Center & Eppley Cancer Center 2005

M.V.Sc Biochemistry and Food Science, Indian Veterinary Research Institute, Barielly, India 1999

B.V.Sc Veterinary and Animal Science, Madras Veterinary College, Madras, India 1997

Research Interests

Dr. Raj’s research focuses on nucleoside drug transporters. Specific areas include overcoming chemoresistance in pancreatic cancer, understanding toxicity of anti-HIV drugs, and studying the role of transporters in human genetic disorders.

Of Note

  • Developmental Research Project Award, Emory University, SPORE in Head and Neck Center, 2008-2010
  • AAPS Award, Exceptional Abstract & Podium Presentation, AAPS Workshop on Drug Transporters, 2011, 2007
  • Training Support Grant, Center for Funding AIDS Research (CFAR), Fred Hutchinson Cancer Center & University of Washington, 2007
  • Reichenbach Presidential Fellowship, University of Nebraska System, 2004-2005
  • Norm and Bernice Harris Award for Outstanding Work in Cancer Research, University of Nebraska Medical Center & Eppley Cancer Center, 2003

Selected Publications

Sau Wai Hung, Hardik Mody, Sean Marrache, Yangzom D. Bhutia, Jason Zastre, Shanta Dhar, Chung K. Chu, and Govindarajan R (2013) Pharmacological Reversal of Histone Methylation Presensitizes Pancreatic Cancer Cells to Nucleoside Drugs: In vitro optimization and novel nanoparticle delivery studies. PLoS ONE; 6;8(8):e711962.

Mourad W. Ali, Ercan Cacan, Yuying Liu, Jennifer Young Pierce, William Creasman, Mandi M. Murph, Govindarajan R, Scott Eblen, Susanna F. Greer, Shelley B. Hooks (2013), Epigenetic suppression of Regulator of G-protein Signaling 10 (RGS10) expression in ovarian cancer cells. PLOS One; 8(3):e60185.

Jason Zastre, Brad Hanberry, Becky Sweet, Kristen Venuti, Cary McGinnis, Michael Bartlett, and Govindarajan R (2013) Vitamin B1 homeostasis in Breast Cancer. J Nutritional Biochemistry; May 1. 2013 Sep;24(9):1616-24.

Bhutia YD, Hung SW, Krentz M, Patel M, Lovin D, Thomson JM, Govindarajan R (2013) Differential processing of let-7a precursors influences gemcitabine chemosensitivity in pancreatic cancer: Role of ribonucleotide reductase subunit M2. PLoS ONE; 8(1):e53436.

Rawal RK, Singh US, Chavre S, Wang J, Sugiyama M, Hung SW,  Govindarajan R, Korba B, Tanaka Y, Chu CK. (2013) 2′-Fluoro-6′-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action.  Bioorganic & Medicinal Chemistry Letters; 23(2):503-6.

Jason Zastre*, Brad Hanberry, Becky Sweet, Kristen Venuti, Cary McGinnis, Michael Bartlett, and Govindarajan R (2013) Vitamin B1 homeostasis in Breast Cancer. J Nutritional Biochemistry (In Press)

Bhutia YD, Hung SW, Krentz M, Patel D, Lovin D, Manoharan R, Thomson JM,Govindarajan R*. Differential Processing of let-7a Precursors Influences RRM2 Expression and Chemosensitivity in Pancreatic Cancer: Role of LIN-28 and SET Oncoprotein. PLoS One. Accepted Nov. 2012. Published 2013 Jan 15.

Rawal RK, Singh US, Chavre SN, Wang J, Sugiyama M, Hung W, Govindarajan R, Korba B, Tanaka Y, Chu CK*. 2′-Fluoro-6′-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action. Bioorg Med Chem Lett. Epub 2012 Nov 24. Published 2013 Jan 15

Bolze A, Abhyankar A, Grant AV, Patel B, Yadav R, Byun M, Caillez D, Lienhardt P-Y, Emile J-F, Pastor-Anglada M, Abel L, Puel A, Govindarajan R, de Pontual L, Casanova J-L* (2012) A mild form of SLC29A3 disorder: A frameshift deletion leads to the paradoxical translation of an otherwise noncoding mRNA splice variant. Plos One, 2012;7(1):e29708. Epub 2012 Jan 4.

Hung SW, Mody H, and Govindarajan R* (2012) Overcoming nucleoside analog chemoresistance in pancreatic cancer: A therapeutic challenge. Cancer Letters Jul 28;320(2):138-49

Bhutia YD, Hung SW, Patel B, Lovin D and Govindarajan R (2011). Restrictive Human Concentrative Nucleoside Transporter-1 Expression Influences Proliferation and Chemosensitization in Drug-Resistant Pancreatic Cancer Cells. Cancer Research 71(5):1825-35.

Govindarajan R, Chakraborty S, Johnson KE, Falk MM, Wheelock MJ, Johnson KR, and Mehta PP (2010) Assembly of Connexin43 into Gap Junctions is Regulated Differentially by E-Cadherin and N-cadherin in Rat Liver Epithelial Cells. Mol. Biol. Cell. (23):4089-107

Kang N, Jun AJ, Bhutia YZ, Kannan N, Unadkat JD and Govindarajan, R. (2010). Human equilibrative nucleoside transporter-3 (hENT3) spectrum disorders mutations impair nucleoside transport, protein localization, and stability. J Biol. Chem. Sep 3; 285(36):28343-52

Govindarajan R, Leung GP, Zhou M, Tse CM, Wang J and Unadkat JD (2009), Facilitated Mitochondrial Import of Anti-viral and Anti-cancer Nucleoside Drugs by Human Equilibrative Nucleoside Transporter-3 (hENT3). Am J Physiol Gastrointest Liver Physiol, 296:G910-G922.

Endres, C., Moss, A., Ban, K., Govindarajan, R. Choi, D.S., Unadkat J. D. (2009). The role of nucleoside transporters in the erythrocyte disposition and oral absorption of ribavirin in the wild-type and equilibrative nucleoside transporter 1-/- mice. J Pharmacol Exp Ther. 1st ed., vol. 331, pp. 287-96.

Veltkamp SA, Pluim D, van Eijndhoven MAJ, Bolijn MJ, Ong FHG, Govindarajan R, et al. (2008), New insights into the pharmacology and cytotoxicity of gemcitabine and 2’, 2’-difluorodeoxyuridine, Mol Cancer Ther., 7(8), 2415-25

Govindarajan R, Endres CJ, Whittington D, LeCluyse E, Pastor-Anglada M, Tse CM, Unadkat JD. (2008) Expression and hepato-biliary transport characteristics of equilibrative and concentrative nucleoside drug transporters in sandwich-cultured human hepatocytes, Am J Physiol Gastrointest Liver Physiol., 295(3):G570-80

Affiliations

Sau Wai Hung, Hardik Mody, Sean Marrache, Yangzom D. Bhutia, Jason Zastre, Shanta Dhar, Chung K. Chu, and Govindarajan R (2013) Pharmacological Reversal of Histone Methylation Presensitizes Pancreatic Cancer Cells to Nucleoside Drugs: In vitro optimization and novel nanoparticle delivery studies. PLoS ONE; 6;8(8):e711962.

Mourad W. Ali, Ercan Cacan, Yuying Liu, Jennifer Young Pierce, William Creasman, Mandi M. Murph, Govindarajan R, Scott Eblen, Susanna F. Greer, Shelley B. Hooks (2013), Epigenetic suppression of Regulator of G-protein Signaling 10 (RGS10) expression in ovarian cancer cells. PLOS One; 8(3):e60185.

Jason Zastre, Brad Hanberry, Becky Sweet, Kristen Venuti, Cary McGinnis, Michael Bartlett, and Govindarajan R (2013) Vitamin B1 homeostasis in Breast Cancer. J Nutritional Biochemistry; May 1. 2013 Sep;24(9):1616-24.

Bhutia YD, Hung SW, Krentz M, Patel M, Lovin D, Thomson JM, Govindarajan R (2013) Differential processing of let-7a precursors influences gemcitabine chemosensitivity in pancreatic cancer: Role of ribonucleotide reductase subunit M2. PLoS ONE; 8(1):e53436.

Rawal RK, Singh US, Chavre S, Wang J, Sugiyama M, Hung SW,  Govindarajan R, Korba B, Tanaka Y, Chu CK. (2013) 2′-Fluoro-6′-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action.  Bioorganic & Medicinal Chemistry Letters; 23(2):503-6.

Jason Zastre*, Brad Hanberry, Becky Sweet, Kristen Venuti, Cary McGinnis, Michael Bartlett, and Govindarajan R (2013) Vitamin B1 homeostasis in Breast Cancer. J Nutritional Biochemistry (In Press)

Bhutia YD, Hung SW, Krentz M, Patel D, Lovin D, Manoharan R, Thomson JM,Govindarajan R*. Differential Processing of let-7a Precursors Influences RRM2 Expression and Chemosensitivity in Pancreatic Cancer: Role of LIN-28 and SET Oncoprotein. PLoS One. Accepted Nov. 2012. Published 2013 Jan 15.

Rawal RK, Singh US, Chavre SN, Wang J, Sugiyama M, Hung W, Govindarajan R, Korba B, Tanaka Y, Chu CK*. 2′-Fluoro-6′-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action. Bioorg Med Chem Lett. Epub 2012 Nov 24. Published 2013 Jan 15

Bolze A, Abhyankar A, Grant AV, Patel B, Yadav R, Byun M, Caillez D, Lienhardt P-Y, Emile J-F, Pastor-Anglada M, Abel L, Puel A, Govindarajan R, de Pontual L, Casanova J-L* (2012) A mild form of SLC29A3 disorder: A frameshift deletion leads to the paradoxical translation of an otherwise noncoding mRNA splice variant. Plos One, 2012;7(1):e29708. Epub 2012 Jan 4.

Hung SW, Mody H, and Govindarajan R* (2012) Overcoming nucleoside analog chemoresistance in pancreatic cancer: A therapeutic challenge. Cancer Letters Jul 28;320(2):138-49

Bhutia YD, Hung SW, Patel B, Lovin D and Govindarajan R (2011). Restrictive Human Concentrative Nucleoside Transporter-1 Expression Influences Proliferation and Chemosensitization in Drug-Resistant Pancreatic Cancer Cells. Cancer Research 71(5):1825-35.

Govindarajan R, Chakraborty S, Johnson KE, Falk MM, Wheelock MJ, Johnson KR, and Mehta PP (2010) Assembly of Connexin43 into Gap Junctions is Regulated Differentially by E-Cadherin and N-cadherin in Rat Liver Epithelial Cells. Mol. Biol. Cell. (23):4089-107

Kang N, Jun AJ, Bhutia YZ, Kannan N, Unadkat JD and Govindarajan, R. (2010). Human equilibrative nucleoside transporter-3 (hENT3) spectrum disorders mutations impair nucleoside transport, protein localization, and stability. J Biol. Chem. Sep 3; 285(36):28343-52

Govindarajan R, Leung GP, Zhou M, Tse CM, Wang J and Unadkat JD (2009), Facilitated Mitochondrial Import of Anti-viral and Anti-cancer Nucleoside Drugs by Human Equilibrative Nucleoside Transporter-3 (hENT3). Am J Physiol Gastrointest Liver Physiol, 296:G910-G922.

Endres, C., Moss, A., Ban, K., Govindarajan, R. Choi, D.S., Unadkat J. D. (2009). The role of nucleoside transporters in the erythrocyte disposition and oral absorption of ribavirin in the wild-type and equilibrative nucleoside transporter 1-/- mice. J Pharmacol Exp Ther. 1st ed., vol. 331, pp. 287-96.

Veltkamp SA, Pluim D, van Eijndhoven MAJ, Bolijn MJ, Ong FHG, Govindarajan R, et al. (2008), New insights into the pharmacology and cytotoxicity of gemcitabine and 2’, 2’-difluorodeoxyuridine, Mol Cancer Ther., 7(8), 2415-25

Govindarajan R, Endres CJ, Whittington D, LeCluyse E, Pastor-Anglada M, Tse CM, Unadkat JD. (2008) Expression and hepato-biliary transport characteristics of equilibrative and concentrative nucleoside drug transporters in sandwich-cultured human hepatocytes, Am J Physiol Gastrointest Liver Physiol., 295(3):G570-80

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