Ph.D. Medicinal Chemistry, University of Florida 1987
B.S. Pharmacy, Medicinal University of South Carolina 1982
B.S. Chemistry, Erskine College 1979
Dr. Beach’s research interests are in the area of the synthesis of compounds as potential treatments for neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. The current series of compounds studied in his lab (in collaboration with Dr. A.V. Terry of Georgia Health Sciences University) have a number of useful therapeutic properties including cognitive enhancement, increasing attention and decreasing/slowing the development of plaque formation in the mouse model of Alzheimer’s disease.
The elucidation of the mechanism of action of these compounds in ongoing. However, current evidence indicates that they seem to be silent desensitizers. These compounds do not cause the activation of the receptor, but cause the receptor to go into an inactive state (closed and unable to be stimulated). This desensitization leads to an up-regulation of beneficial cascades within the cell.
Israel, B ; Garner, ST; Thakare, M ; Elder, D ; Abney, T ; Azadi, P ; Beach, JW ; Price, JC ; Ahmed, H ; Capomacchia, AC. (2012). Transdermal permeation of novel n-acetyl-glucosamine/NSAIDs mutual prodrugs. Pharmaceutical Development & Technology 17(1): 48-54. DOI: 10.3109/10837450.2010.513987
Keowkase, Roongpetch, Aboukhatwa, Marwa, Adam, Bao-Ling, Beach, J. Warren, Terry, Alvin V., Jr., Buccafussco, Jerry J., Luo, Yuan. (2010). Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans. Molecular Neurodegeneration, 2010 5(59).
J J. Buccafusco, J. W. Beach and A. V. Terry Jr. (2009). Desensitization of Nicotinic Acetylcholine Receptors as a Strategy for Drug Development. J. Pharm. Exper. Ther., 2009 328:364-370.
A. Sood , J. W. Beach, S. J. Webster, A. V. Terry, Jr., J. J. Buccafusco. (2007). The effects of JWB1-84-1 on memory-related task performance by amyloid Ab transgenic mice and by young and aged monkeys. J. Neuropharm. 2007 53(5): 588-600.
J. Nerurkar, J.W. Beach, M.O. Park, H.W. Jun. Solubility of (+/-)-ibuprofen and S (+/-)-ibuprofen in the presence of cosolvents and cyclodextrins. Pharmaceutical Development and Technology 2005 10(3): 413-421.
*Buccafusco JJ, Beach JW, Terry AV, Doad GS, Sood A, Arias E, Misawa H, Masai M, Fujii T, Kawashima K. Novel analogs of choline as potential neuroprotective agents. Journal of Alzheimers Disease, 2004 6(6) S85-S92 Suppl.