Liza Ngo, MS


Liza Ngo, MS

Major Professor: Dr. Yujun George Zheng
Liza Ngo

Education

M.S. Biology, Georgia State University, Atlanta, GA 2013

B.S. Biology, Georgia State University, Atlanta, GA 2011

Research Interests

Histone acetyltransferases (HATs) mediate the transfer of an acetyl group from the cofactor, acetyl-CoA, to the ε- amino group of specific lysines in diverse protein substrates, most notably nuclear histones. HATs are classified into several main families which include GCN5/PCAF, MYST, and CBP/p300 [1]. The deregulation of HATs is connected to a number of disease states [2, 3]. Reliable and rapid biochemical assays for HATs are critical for understanding biological functions of protein acetylation, as well as for screening small-molecule inhibitors of HAT enzymes. I am interested in designing novel chemical biology tools and methods to detect HAT enzymatic activity.

Selected Publications

Marmorstein, R., Structure and function of histone acetyltransferases. Cell Mol Life Sci, 2001. 58(5-6): p. 693-703.

Gusterson, R.J., et al., The Transcriptional Co-activators CREB-binding Protein (CBP) and p300 Play a Critical Role in Cardiac Hypertrophy That Is Dependent on Their Histone Acetyltransferase Activity. Journal of Biological Chemistry, 2003. 278(9): p. 6838-6847.

Isharwal, S., et al., p300 (histone acetyltransferase) biomarker predicts prostate cancer biochemical recurrence and correlates with changes in epithelia nuclear size and shape. The Prostate, 2008. 68(10): p. 1097-1104.

Of Note

  • Pharmaceutical and Biomedical Science outstanding Junior Graduate Student of the Year, 2015
  • National Science Foundation Graduate Research Fellowship Program, 2015 – present
  • Biotech scholars, 2011
  • Molecular Basis of Disease Program, 2011
  • Louis Stokes Alliances for Minority Participation (LSAMP), 2010